Jimenez-Mateos et al (2011) miRNA Expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132.

Animal study: Mouse model (intra-amygdala kainate) and analysis of CA3 subfield of hippocampus at 24 h (TLDA platform). Post-hoc validation using PCR (Taqman assay) and Ago2 pull-downs (RISC analysis) accompanied by functional study using antagomirs against miR-132. Targeting miR-132 reduced hippocampal damaged after status epilepticus but did not alter acute seizure severity.
Jimenez-Mateos et al (2011)