Jimenez-Mateos et al (2012) Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects.

Animal and human studies: Mouse model (intra-amygdala kainate) and analysis of resected neocortex from TLE patients. miR-134 upregulated in both studies (PCR/Taqman assays in situ hybridization and Ago2 analysis). Targeting miR-134 reduced kainate seizure severity in pre-treatment tests and reduced the later occurence of spontaenous seizures in post-treatment tests.
Jimenez-Mateos et al (2012)